![]() We use a 3 to 1 ratio that is consistent with CMS, the State of Oregon PDMP, and research studies by Von Korff (Clin J Pain 2008 24:521-7) and Krebs (Pain 2011 152:1789-95). Hydrocodone is used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time. Tramadol is available in immediate-release doses of 50 mg and 100 mg tablets and extended-release capsules of 100 mg and 150 mg. But 300 mg of tramadol would be equivalent to one 30 mg dose of morphine or hydrocodone. There is limited evidence and no consensus on the conversion factors to use for methadone. One 30-milligram (mg) dose of hydrocodone is equivalent to one 30 mg dose of morphine. Increasing methadone doses over 30 mg/day is not recommended. Oral Solution: Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL: Initial dose: 15 mL every 4 to 6 hours as needed for pain Maximum dose: 90 mL/24 hours Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL: Initial dose: 11.25 mL every 4 to 6 hours as needed for pain Maximum dose: 67. Methadone should not be the first choice for an ER/LA opioid. All doses were converted to morphine equivalent doses (conversion factors: oxyco- done, 1.5 hydrocodone, 1.0).15 Opioid dose was calcu- lated at the index. It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, or patients with cancer. In addition, methadone is associated with cardiac arrhythmias along with QT prolongation on the electrocardiogram. Go to: Continuing Education Activity Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. Dosage Print Save Hydrocodone Dosage Medically reviewed by. ![]() Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, and severe central nervous system depression. Methadone has been associated with disproportionate numbers of overdose deaths relative to the frequency with which it is prescribed for chronic pain, due in part to its long and variable half-life. Benzhydrocodone is a hydrocodone prodrug that is rapidly converted into hydrocodone in the gastrointestinal tract.
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